Perinatal deaths account for 7% of the global burden of disease. Accurate diagnosis of the cause of fetal, perinatal, and neonatal death is important for the prevention of deaths and morbidity in subsequent pregnancies. In fifty percent of the cases, the certified cause of death can be discordant from the actual cause of death and hence the need for a post-mortem examination. A conventional autopsy is a gold standard in confirming and establishing the cause of death in the perinatal and neonatal period especially when clinical manifestations are nonspecific. It includes a thorough examination of the whole body with dissection of organs and body cavities, followed by sectioning of relevant tissues to establish the cause of death and the effectiveness and side effects of therapies. India being a conservative multicultural nation, many parents refuse to consent for autopsy in neonates due to religious, emotional attachment, and cultural reasons. Public reluctance for autopsy has increased over time, more so due to adverse media attention, delay in last rites, and spiritual or ethnic views, and fear of disfigurement of the deceased’s body, has led to refusal for conventional autopsy and preferential acceptance for Minimally Invasive Tissue Sampling (MITS). It is a feasible and less traumatic technique that would circumvent the need for a complete autopsy in determining the cause of death. This technique is less invasive and time-consuming and practical in socially constrained areas.