India has 13,295 active COVID-19 cases with death toll reaching 519 as of 19th April 2020. There is an urgent need to explore novel options of treatment for COVID-19. Despite standard treatment, 20% of patient’s progress to moderate stage out of which 5% deteriorate to severe stage and the mortality rate is 3%. Ozone therapy, an integral part of Naturopathic medicine extensively been used for treating chronic diseases since many years.COVID-19 exhibits multimodal pathology by inducing a ‘cytokine storm’ primed to exacerbate the inflammatory response, depleted oxygenation and viral infection leading to pneumonia, edema, respiratory failure and eventually, death. Ozone therapy has been shown to mitigate inflammatory cytokine storms in a variety of disorders, including respiratory disorders. It has potent antiviral, anti-inflammatory and immunomodulatory effects. Recent reports from Balearic Islands reveals that no new cases of COVID-19 following the administration of ozone therapy by a clinic in Spain. Several clinical trials are under way for testing the safety and efficacy of ozone therapy against COVID-19, with no reports of adverse events so far. The present study is proposed to evaluate the utility of ozone therapy as an adjuvant along with standard care in control of disease progression in patients COVID-19.