COVID -19 pandemic has affected the world cutting across geographical, cultural or religious boundaries. With more than 4.5 million COVID positives and three hundred thousand deaths, it has emerged as most dangerous threat and tragedy to human race.

Since till date no effective treatment is available, need is to look for drugs with potential in reducing viral replication. Lithium carbonated which is being prescibed for Bipolar disorder have shown potential in many invitro studies to inhibit other avian corona virus growth in cell culture.It directly impedes viral replication in animal and in vitro studies. This was first discovered in the 1980’s with the herpes family of viruses. Lithium treated and prevented labile herpes, whether taken orally or as a topical ointment. Since then, lithium has demonstrated antiviral activity against over a dozen viruses, both DNA and RNA types. Studies have shown that porcine epidemic diarrhoea virus (PEDV), a member of the Coronaviridae family, requires the P13K/Akt/GSK-3a/b pathway, which can be targeted at GSK-3b by lithium.

We will be enrolling 100 patients of Covid 19 who are severely symptomatic, divide them in 2 groups, one group will received standard care of therapy i.e. hydroxycloroquine, azithromycin or both and other group will receive Lithium carbonate at dose of 600mg twice daily with standard care of therapy for 6 days.